Sodium Picosulphate works by encouraging the muscles in your bowel to move waste products through your body. Sodium Picosulphate a laxative that works by drawing large amounts of water into your intestines and stimulating the colon. Sodium Picosulphate is used to clean out the intestines before surgery or certain procedures (such as colonoscopy, X-rays). This causes watery bowel movements (diarrhea). Sodium Picosulphate used to Clear stool from the intestines, that helps your doctor to better examine the inside of your colon.