Imatinib 400mg for Chronic Myeloid Leukemia and More
IMATIFLOW 400 is an oral anticancer medication containing Imatinib IP 400mg, designed to treat certain types of cancers, primarily chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GISTs). As a tyrosine kinase inhibitor (TKI), Imatinib works by blocking abnormal proteins that promote the growth of cancer cells. The formulation in IMATIFLOW 400 ensures effective and sustained delivery of the active ingredient, helping patients achieve long-term disease control and improved quality of life.
What is IMATIFLOW 400?
IMATIFLOW 400 is a prescription medication that contains Imatinib Mesylate, equivalent to Imatinib IP 400mg per tablet. It belongs to a class of targeted therapies known as tyrosine kinase inhibitors, which are widely used in the treatment of cancers driven by abnormal enzyme signaling. Imatinib has revolutionized the management of certain blood and soft tissue cancers by selectively targeting the proteins involved in tumor development.
Composition
Each film-coated tablet of IMATIFLOW 400 contains:
Imatinib IP 400mg
It is formulated for oral administration and should be taken under the supervision of a qualified healthcare professional.
Mechanism of Action: How Does Imatinib 400 Work?
Imatinib 400, the active agent in IMATIFLOW 400, works by inhibiting the activity of specific tyrosine kinases, including:
BCR-ABL (the abnormal fusion protein in chronic myeloid leukemia)
c-KIT (found in gastrointestinal stromal tumors)
PDGFR (platelet-derived growth factor receptor, involved in some rare tumors)
These kinases are enzymes that play a key role in cell signaling, growth, and division. In certain cancers, these enzymes are overactive or mutated, leading to uncontrolled cell proliferation. Imatinib 400 binds to these proteins and blocks their activity, thereby slowing or stopping the growth of cancer cells.
Therapeutic Uses of IMATIFLOW 400
IMATIFLOW 400 is indicated in the treatment of several types of cancers and blood disorders, including:
1. Chronic Myeloid Leukemia (CML)
In chronic, accelerated, or blast crisis phases
For newly diagnosed adult and pediatric patients with Philadelphia chromosome-positive CML
2. Acute Lymphoblastic Leukemia (ALL)
Particularly Philadelphia chromosome-positive (Ph+ ALL) in adults and children
3. Gastrointestinal Stromal Tumors (GISTs)
Unresectable or metastatic GISTs
As adjuvant therapy after surgical removal of tumors
4. Myelodysplastic/Myeloproliferative Diseases
Associated with PDGFR gene rearrangements
5. Hypereosinophilic Syndrome (HES) and Chronic Eosinophilic Leukemia (CEL)
Key Benefits of IMATIFLOW 400
Targeted action with minimal impact on healthy cells
Proven efficacy in extending survival rates in CML and GIST patients
Reduces tumor size and disease progression
Improves hematological and cytogenetic response in blood cancers
Allows for long-term disease management with regular monitoring
Dosage and Administration
IMATIFLOW 400 is available in tablet form and should be taken once daily with a full glass of water, preferably after a meal to reduce gastrointestinal side effects.
Common dosing guidelines:
CML (chronic phase): 400 mg once daily
CML (advanced stages): May be increased to 600–800 mg per day based on response
GISTs: Usually 400–600 mg per day
Note: Doses may be adjusted based on patient tolerance, blood counts, and response to therapy. Always follow the doctor’s prescribed regimen.
Side Effects of Imatinib 400
Like all medications, Imatinib 400 can cause side effects, although not everyone experiences them. Common side effects include:
Nausea, vomiting, or abdominal pain
Muscle cramps or joint pain
Fatigue or weakness
Edema (swelling, especially around the eyes or ankles)
Skin rash or itching
Headache and dizziness
Diarrhea or constipation
Serious side effects (rare but possible) include liver toxicity, low blood cell counts, heart problems, or severe allergic reactions. Regular monitoring through blood tests is essential during treatment.
Precautions and Warnings
Not recommended during pregnancy or breastfeeding unless advised by a physician
Regular blood tests (CBC, liver function, kidney function) are necessary to monitor safety and efficacy
Use caution in patients with liver or kidney disease
Avoid taking other medications without medical advice due to possible drug interactions
Drug Interactions
Imatinib may interact with:
Blood thinners (e.g., warfarin)
Anti-seizure medications
Certain antibiotics or antifungals
Herbal supplements (especially St. John’s Wort)
Always inform your doctor about all medications and supplements you are taking.
Conclusion
IMATIFLOW 400, containing Imatinib 400, stands as a cornerstone in the treatment of several cancers, especially chronic myeloid leukemia and gastrointestinal stromal tumors. With its targeted mechanism, predictable response, and well-documented clinical success, it has significantly improved outcomes and survival rates for many patients worldwide.
Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options. The company offers a wide range of healthcare products, catering to various medical needs, from rare disease treatments to essential healthcare products. Sterispharma's product range includes solutions for Cardiology, Asthma, Respiratory Issues, Nasal Conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/Antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental Care, and Dermatology. Medicines can be conveniently ordered via Our websites—Sterisonline, Sterisindia, and Sterispharma.
For further information
Email: info@sterispharma.com / contact@sterispharma.com
Call/WhatsApp: 8209542042 , 8824175417
