GLISITAPTIN 100

Description

Sitagliptin Phosphate 100 mg Sitagliptin Phosphate 100 mg is an oral antidiabetic medication belonging to the class of Dipeptidyl Peptidase-4 (DPP-4) inhibitors, used for the management of Type 2 Diabetes Mellitus (T2DM). It is designed to improve glycemic control by regulating insulin levels after meals without causing significant weight gain or hypoglycemia. Sitagliptin is often prescribed alone or in combination with other antidiabetic medications like metformin, sulfonylureas, or SGLT2 inhibitors. Uses of Sitagliptin Phosphate 100 mg Sitagliptin Phosphate 100 mg tablet is primarily used for the treatment of: Type 2 Diabetes Mellitus in adults As monotherapy when diet and exercise alone are not sufficient As combination therapy with other oral antidiabetics or insulin when monotherapy fails Reducing HbA1c (glycated hemoglobin) and fasting/postprandial blood glucose levels Benefits of Sitagliptin Phosphate 100 mg Improves insulin secretion and reduces glucagon levels in response to meals Helps maintain consistent blood sugar control Low risk of hypoglycemia when used as monotherapy Weight-neutral profile, making it suitable for overweight or obese patients Convenient once-daily oral dose Can be safely used in elderly patients Compatible with combination therapy for better glycemic control Sitagliptin works by inhibiting the DPP-4 enzyme, which increases the levels of incretin hormones (GLP-1 and GIP), enhancing insulin release and lowering glucose production from the liver. Dosage of Sitagliptin Phosphate 100 mg The typical recommended dosage of Sitagliptin Phosphate is: 100 mg once daily, with or without food Special Dosage Considerations: Renal impairment: Moderate (eGFR ≥30 to <45 mL/min/1.73 m²): 50 mg once daily Severe (eGFR <30): 25 mg once daily No dose adjustment is required in mild renal impairment Always follow the prescribed dosage schedule by your doctor. Do not double the dose or stop medication without consulting a healthcare professional. Side Effects of Sitagliptin Phosphate 100 mg While Sitagliptin 100 mg is generally well tolerated, some patients may experience side effects. These are usually mild and transient. Common Side Effects: Headache Nasopharyngitis (cold-like symptoms) Upper respiratory tract infections Stomach discomfort or indigestion Less Common/Serious Side Effects: Hypoglycemia (more likely when combined with sulfonylureas or insulin) Pancreatitis (rare, but serious) Skin reactions like rash or itching Joint pain (severe and disabling in rare cases) Allergic reactions (swelling of face, lips, tongue) Seek immediate medical attention if any symptoms of pancreatitis, severe joint pain, or allergic reactions occur.