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SACUBRIGHT 50 Sacubitril (24mg), Valsartan (26mg) SACUBRIGHT is a medication used primarily in the treatment of heart failure. SACUBRIGHT is marketed under the brand name Entresto, among others, and represents a novel class of medication known as angiotensin receptor-neprilysin inhibitors (ARNIs). SACUBRIGHT works in a unique way to help relax blood vessels and improve blood flow, as well as reduce the strain on the heart, making it a valuable option for patients with certain types of heart failure. Mechanism of Action: Sacubitril is a prodrug that is converted to an active metabolite which inhibits neprilysin, an enzyme responsible for the degradation of natriuretic peptides, among other substances. Natriuretic peptides are involved in the regulation of blood volume, pressure, and sodium balance. By inhibiting neprilysin, sacubitril leads to increased levels of these peptides, which helps to reduce blood pressure and sodium retention, leading to a reduction in blood volume and improvement in symptoms of heart failure. Valsartan is an angiotensin II receptor blocker (ARB). It blocks the action of angiotensin II, a potent vasoconstrictor, on its receptors, leading to relaxation of blood vessels, reduced blood pressure, and a decrease in the workload on the heart. Indications: SACUBRIGHT is specifically indicated for the treatment of heart failure with reduced ejection fraction (HFrEF), which is a condition where the heart muscle does not contract effectively, and less oxygen-rich blood is pumped out to the body. Clinical trials have shown that sacubitril/valsartan reduces the risk of death and hospitalization for patients with heart failure compared to enalapril, a standard treatment for heart failure. Usage: It is important to use SACUBRIGHT under the guidance of a healthcare provider, as it requires monitoring for potential side effects and adjustments based on individual response and tolerance. The dose of sacubitril/valsartan is typically titrated based on the patient's condition and how well they tolerate the medication. For further information please contact: info@sterispharma.com / contact@sterispharma.com call/whatsapp: 8209542042, 8955945010,7877551268, 6377716668, order now: https://www.sterisonline.com/product/sacubright-50-134202
