Glimepiride & Metformin Hydrochloride Prolonged Release combines two drugs medicine is used in the treatment of type 2 diabetes mellitus (DM). Introduction to GLIMITERIS M1 GLIMITERIS M1 is a combination medication designed to manage type 2 diabetes mellitus effectively. It contains Glimepiride, a sulfonylurea, and Metformin Hydrochloride in a prolonged-release (PR) formulation. This dual-action formula targets different aspects of glucose regulation to provide comprehensive blood sugar control. GLIMITERIS M1 is used alongside diet and exercise to improve glycemic control in adults with type 2 diabetes. Key Components and Their Mechanisms Glimepiride Glimepiride is a potent sulfonylurea that works by: Stimulating Insulin Secretion: Glimepiride stimulates the pancreas to release more insulin, which helps lower blood sugar levels, particularly after meals. Improving Insulin Sensitivity: It enhances the body’s response to insulin, making it more effective at lowering blood sugar levels. Metformin Hydrochloride (Prolonged Release) Metformin is a biguanide that helps lower blood sugar levels through several mechanisms: Reducing Hepatic Glucose Production: Metformin decreases the amount of glucose produced by the liver. Improving Insulin Sensitivity: It enhances the sensitivity of muscle cells to insulin, promoting better glucose uptake and utilization. Decreasing Intestinal Absorption of Glucose: Metformin reduces the absorption of glucose from the gastrointestinal tract. The prolonged-release (PR) formulation ensures a gradual release of the medication, providing prolonged therapeutic effects and reducing the risk of gastrointestinal side effects. Benefits of GLIMITERIS M1 Comprehensive Blood Sugar Control Fasting and Postprandial Glucose Management: The combination of Glimepiride and Metformin effectively manages both fasting and postprandial (after-meal) blood sugar levels. Enhanced Insulin Secretion and Sensitivity: Glimepiride enhances insulin secretion, while Metformin improves insulin sensitivity and reduces hepatic glucose production. Prolonged-Release Formulation Extended Relief: The prolonged-release formulation of Metformin ensures a steady release of the medication, providing long-lasting blood sugar control and minimizing peaks and troughs in blood sugar levels. Reduced Gastrointestinal Side Effects: The gradual release of Metformin helps reduce common gastrointestinal side effects associated with immediate-release formulations. How to Use GLIMITERIS M1 Dosage and Administration Recommended Dosage: The typical dosage is one GLIMITERIS M1 tablet taken once or twice daily, or as prescribed by your healthcare provider. Administration: Swallow the tablet whole with a full glass of water. Do not crush, chew, or split the tablet, as this can affect the prolonged-release properties of the medication. It is best taken with meals to reduce gastrointestinal side effects. Guidelines for Optimal Use Consistent Use: For best results, take GLIMITERIS M1 regularly at the same time each day as prescribed by your healthcare provider. Monitor Blood Sugar Levels: Regular monitoring of blood sugar levels is important to ensure the medication is effectively controlling your diabetes. Adjustments to your treatment plan may be necessary based on these readings.