Nebivolol 2.5mg NEBIVALVE 2.5 is a unique beta-blocker used primarily in the treatment of hypertension (high blood pressure) and, in some cases, heart failure. NEBIVALVE 2.5 stands out from other beta-blockers due to its distinct mechanism of action, which includes both beta-adrenergic receptor blockade and nitric oxide-dependent vasodilation, offering some advantages in terms of side effect profiles and potential benefits for certain patient populations. Mechanism of Action Beta-1 Selective Blockade: NEBIVALVE 2.5 selectively blocks beta-1 adrenergic receptors in the heart, which reduces heart rate and myocardial contractility. This helps to lower blood pressure and reduce the heart's workload. Nitric Oxide Release: NEBIVALVE 2.5 enhances the release of nitric oxide (NO) from the endothelium (lining of the blood vessels). This NO-mediated vasodilation contributes to its antihypertensive effects by reducing vascular resistance. Uses Hypertension: NEBIVALVE 2.5 is primarily used to manage high blood pressure. It can be used alone or in combination with other antihypertensive agents. Heart Failure: Although less common, nebivolol may also be used in the treatment of heart failure, particularly in Europe, based on evidence suggesting benefits in certain patient groups.