ST-GLIPTIN M 100/1000 is a combination oral anti-diabetic medication designed for the effective management of type 2 diabetes mellitus. Formulated with Sitagliptin and Metformin Hydrochloride, this dual-action therapy helps regulate blood sugar levels in adults who are unable to achieve adequate glycemic control through diet and exercise alone. This medication supports long-term glucose regulation and reduces the risk of diabetes-related complications. Key Ingredients Sitagliptin (100 mg): A DPP-4 (dipeptidyl peptidase-4) inhibitor that enhances the body's natural ability to control blood sugar levels by increasing the activity of incretin hormones. These hormones stimulate insulin release and suppress glucagon production in a glucose-dependent manner. Metformin Hydrochloride (1000 mg): A biguanide that decreases glucose production in the liver, improves insulin sensitivity, and increases glucose uptake by muscle cells. Metformin is known for its ability to manage blood glucose without causing significant weight gain or hypoglycemia. Key Benefits Improves glycemic control in adults with type 2 diabetes mellitus Reduces fasting and postprandial blood glucose levels Supports weight neutrality or slight weight loss Decreases insulin resistance and improves insulin sensitivity Reduces the risk of diabetes-related complications such as neuropathy, nephropathy, and cardiovascular diseases Minimizes the need for insulin or other medications when used as part of a comprehensive treatment plan How Does It Work? ST-GLIPTIN M 100/1000 works through a synergistic mechanism combining the benefits of Sitagliptin and Metformin. Sitagliptin inhibits the enzyme DPP-4, which increases the levels of active incretin hormones. These hormones promote insulin secretion from the pancreas and reduce the release of glucagon, particularly after meals. This helps in lowering blood sugar spikes following food intake. Metformin complements this action by decreasing hepatic glucose output and improving peripheral glucose uptake. Together, these actions effectively lower blood glucose levels without causing significant hypoglycemia and with a favorable impact on body weight. Directions for Use Take ST-GLIPTIN M 100/1000 as prescribed by your healthcare provider. It is usually taken once or twice daily with meals to reduce gastrointestinal side effects. Swallow the tablet whole with water, and do not crush or chew it. Always follow your physician’s guidance regarding diet, physical activity, and blood sugar monitoring while using this medication. Side Effects While ST-GLIPTIN M 100/1000 is generally well-tolerated, some patients may experience side effects, which can include: Gastrointestinal discomfort (nausea, diarrhea, bloating) Headache or dizziness Upper respiratory tract infections Vitamin B12 deficiency with prolonged use Lactic acidosis (a rare but serious condition, particularly in individuals with kidney impairment or dehydration) Hypoglycemia (when combined with other anti-diabetic medications or in case of skipped meals) If you experience any severe or persistent side effects, consult your healthcare provider immediately.