CYCLOPURE 50

Description

Introduction CYCLOPURE 50 is a highly effective immunosuppressive therapy containing Cyclosporine 50 mg, a calcineurin inhibitor used to prevent organ transplant rejection and treat several autoimmune disorders. This formulation—Cyclosporine Capsules IP 50 mg—is ideal for patients requiring higher dosing strength for maintenance therapy or autoimmune disease management. What is CYCLOPURE 50 (Cyclosporine 50 mg Capsule)? CYCLOPURE 50 contains Cyclosporine, an immunomodulatory drug originally derived from the fungus Tolypocladium inflatum. It plays a crucial role in controlling abnormal immune responses. The capsule formulation allows for easy swallowing and steady absorption in transplant and autoimmune disease patients. Uses of Cyclosporine 50 mg Capsules (CYCLOPURE 50) CYCLOPURE 50 is prescribed for: 1. Organ Transplantation: Kidney transplant Liver transplant Heart transplant It helps prevent organ rejection by reducing the immune response against the graft. 2. Autoimmune Disorders: Rheumatoid Arthritis Psoriasis (severe, plaque-type) Nephrotic Syndrome (especially steroid-resistant) Uveitis (non-infectious inflammatory eye disease) 3. Off-Label Uses (under strict medical supervision): Alopecia Areata Atopic Dermatitis Crohn’s Disease Mechanism of Action of Cyclosporine Cyclosporine works by: Binding to cyclophilin, a protein in immune cells. This complex inhibits calcineurin, an essential enzyme for activating T-lymphocytes. Inhibition of calcineurin prevents the transcription of interleukin-2 (IL-2) and other cytokines. This action suppresses the immune system's overreaction, helping prevent inflammation and graft rejection. Side Effects of CYCLOPURE 50 (Cyclosporine 50 mg Side Effects) Common Side Effects: Headache Tremor Nausea and vomiting Hypertension (high blood pressure) Increased hair growth (hirsutism) Swollen gums (gingival hyperplasia) Serious Side Effects: Nephrotoxicity (kidney damage) Hepatotoxicity (liver dysfunction) Increased risk of infections Risk of malignancies (especially skin cancer and lymphoma with prolonged use) Elevated cholesterol or triglyceride levels Seek immediate medical help if symptoms like difficulty urinating, vision problems, or persistent fatigue occur. Precautions Before Using Cyclosporine 50 mg Capsules Before using CYCLOPURE 50, tell your doctor if you: Have kidney or liver disease Suffer from uncontrolled hypertension Are pregnant or breastfeeding Have a history of cancer or immune deficiency Are taking multiple medications or herbal supplements Important Safety Tips: Avoid grapefruit or grapefruit juice – it can raise cyclosporine levels dangerously. Avoid sun exposure and always use sunscreen – reduces cancer risk. Frequent monitoring of blood pressure, kidney function, and cyclosporine levels is necessary. Drug Interactions What Drugs Interact with Cyclosporine 50 mg? Cyclosporine has significant drug interaction potential: Increases cyclosporine levels (risk of toxicity): Macrolide antibiotics: Erythromycin, Clarithromycin Azole antifungals: Ketoconazole, Itraconazole Calcium channel blockers: Verapamil, Diltiazem HIV protease inhibitors Decreases cyclosporine levels (reduces efficacy): Rifampin Phenytoin Carbamazepine St. John’s Wort Other Interactions: NSAIDs (e.g., ibuprofen): Can increase kidney damage Statins: May increase the risk of rhabdomyolysis Diuretics: May increase potassium levels Always inform your healthcare provider about all medications and supplements you're using. Conclusion CYCLOPURE 50 (Cyclosporine 50 mg Capsules IP) is an essential immunosuppressive therapy that offers reliable protection against organ rejection and effectively manages autoimmune diseases. Its precise mechanism of action allows for immune control without widespread suppression, making it a preferred choice in clinical practice. With regular monitoring and correct dosing, CYCLOPURE 50 ensures a balance between therapeutic benefit and safety. Always use it under the guidance of a qualified medical professional.