Introduction
ENZULAMIDE 160 (chemical composition Enzalutamide 160mg is an advanced oral medication prescribed primarily for the treatment of metastatic castration-resistant prostate cancer (mCRPC). As a nonsteroidal anti-androgen, ENZULAMIDE 160 is integral when cancers are resistant to conventional hormonal therapy. Its role in modern cancer care is vital, offering hope for men with advanced disease who have not responded to other forms of treatment.
Mechanism of Action
Enzalutamide 160 mg works by strongly blocking androgen receptors in prostate cancer cells, which prevents male hormones (androgens) like testosterone from stimulating cancer growth. Specifically, it inhibits multiple steps in the androgen receptor signaling pathway, including preventing receptor movement to the cell nucleus and DNA binding—significantly reducing tumor proliferation.
Uses and Indications
Primary use: Treatment of advanced prostate cancer, especially metastatic castration-resistant prostate cancer (mCRPC) where conventional therapies have failed.
It is also researched for potential enzalutamide use in hormone-sensitive and non-metastatic diseases, but the main, well-established indication remains mCRPC.
Dosage and Administration
The recommended dosage: 160 mg once daily (typically as four 40 mg capsules), with or without food. It's advised to take the medication at the same time daily.
Swallow capsules whole; do not open, crush, or chew.
Missed dose: Take as soon as remembered unless it is almost time for the next dose—do not double up on doses.
Dose adjustment: In case of strong CYP2C8 inhibitors, the dose may be reduced; consult your doctor if you are on such medications.
Efficacy and Clinical Evidence
AFFIRM trial: Enzalutamide significantly improves overall survival in men with mCRPC after chemotherapy, delays skeletal events, and improves quality of life.
PREVAIL study: Showed reduced risk of progression or death in chemotherapy-naïve patients with mCRPC versus placebo. Multiple secondary benefits include delayed time to chemotherapy, improved PSA response, and pain outcomes
Enzalutamide's results have been consistent and positive across various subgroups and phases of prostate cancer.
Enzalutamide Side Effects and Safety Profile
Common Side Effects
Fatigue, hot flashes, hypertension, headache, dizziness, dry or itchy skin, memory/concentration problems, and musculoskeletal pain are frequently reported.
Gastrointestinal symptoms: diarrhea, constipation.
Changes in appetite or weight.
Gynecomastia (breast swelling) in men.
Insomnia, anxiety.
Serious Side Effects
Seizures, confusion, loss of consciousness
Cardiovascular risks: High blood pressure, coronary artery disease.
Falls and bone fractures
Swelling, difficulty urinating, or blood in urine
Rare: breast enlargement, severe allergies.
Contraindications and Precautions
Not recommended during pregnancy or breastfeeding.
Use caution in patients with history of seizures or neurological disorders.
Caution is advised for patients with renal or hepatic impairment.
Discontinue or adjust dose in case of severe toxicity (Grade 3 or above).
Drug Interactions
Enzalutamide has over 680 known drug interactions: 250 major, 416 moderate, 14 minor.
It is a moderate inducer of CYP2C9, CYP2C19, and CYP3A4, and it can significantly decrease levels of certain medications (e.g., warfarin, statins, some antidepressants, certain anticancer drugs).
Check with your healthcare provider/pharmacist about all medications, supplements, and herbal products before starting enzalutamide.
Warnings and Regulatory Status
FDA-approved for mCRPC use (marketed as Xtandi).
Restricted for use only under specialist supervision.
Patients should be aware of the risks of seizures and interactions.
Monitor for hypertension and cardiovascular events.
Patient Advice and Tips
Take tab enzalutamide 160 mg at the same time daily.
Do not stop or alter dose without consulting your provider.
Monitor for side effects, particularly changes in cognition, fatigue, or seizures, and report them.
Blood pressure and bone health should be regularly checked.
Availability
ENZULAMIDE 160 mg is available in India from leading pharmaceutical companies, including Steris Healthcare and others, both in hospital and retail settings.
Supplied as tablets or capsules in prescription-only packs.
Frequently Asked Questions:
Q: Who should not take Enzalutamide?
A: Those who are allergic to Enzalutamide, pregnant women, and patients with severe liver or kidney problems without specialist advice.
Q: Can it be taken with food?
A: Yes, enzalutamide 160 mg can be taken with or without food.
Q: Will it cure prostate cancer?
A: It does not cure but significantly delays progression of advanced prostate cancer and improves survival.
Why Choose Steris Healthcare?
Steris Healthcare manufactures high-quality, reliable enzalutamide formulations that meet international standards.
Widely available in India, ensuring accessibility for patients requiring enzalutamide 160 mg for advanced prostate cancer.
Conclusion
Enzalutamide 160 mg (ENZULAMIDE 160) is a highly effective therapy for men battling advanced prostate cancer. With proven clinical efficacy and a well-characterized safety profile, it represents a cornerstone treatment in modern oncology. However, its use requires careful monitoring, awareness of side effects, and a commitment to following medical advice. For patients and caregivers navigating prostate cancer, ENZULAMIDE 160 offers extended survival, improved quality of life, and renewed hope.
