Introduction
Steriscox MR 4 is a combination medicine containing etoricoxib 60mg thiocolchicoside 4mg, designed to relieve pain and muscle spasms caused by inflammatory and musculoskeletal conditions. This formulation combines the anti-inflammatory and analgesic properties of etoricoxib with the muscle relaxant effects of thiocolchicoside for enhanced therapeutic benefit.
Mechanism of Action:
Etoricoxib is a selective COX-2 inhibitor belonging to the class of non-steroidal anti-inflammatory drugs (NSAIDs). It reduces pain and inflammation by selectively blocking the cyclo-oxygenase-2 (COX-2) enzyme, preventing the formation of prostaglandins responsible for inflammation, pain, and swelling. This selectivity helps minimize gastrointestinal side effects compared to non-selective NSAIDs. Thiocolchicoside acts as a muscle relaxant mainly by binding to GABA-A (gamma-aminobutyric acid) receptors and glycine receptors in the central nervous system. It inhibits muscle contractions by modulating inhibitory neurotransmission pathways, thereby reducing muscle stiffness and spasms
Etoricoxib Thiocolchicoside tablets Uses :
This etoricoxib thiocolchicoside tablets combination is prescribed for treating painful muscle spasms associated with conditions such as low back pain, muscle strains, spondylitis, osteoarthritis, rheumatoid arthritis, gout, and other musculoskeletal disorders. It helps alleviate pain, inflammation, and muscle stiffness to improve mobility and patient comfort
Efficacy and Clinical Evidence:
Clinical studies have demonstrated that the combination of etoricoxib thiocolchicoside provides faster and more effective pain relief compared to thiocolchicoside alone in patients with painful muscle spasms. The dual action on inflammation and muscle relaxation results in improved functional recovery and patient-reported outcomes. It is well tolerated with a manageable side effect profile.
Side Effects and Safety Profile:
Common side effects reported with tab etoricoxib thiocolchicoside include gastrointestinal discomfort such as nausea, dyspepsia, abdominal pain, diarrhea, and flatulence. Dizziness, headache, drowsiness, and edema may also occur. Rare but serious adverse effects could involve cardiovascular events due to COX-2 inhibition and potential allergic reactions. Thiocolchicoside may cause sedation and should be used cautiously in seizure-prone individuals
Contraindications and Precautions:
Steriscox MR 4 should not be used in patients with known hypersensitivity to etoricoxib, thiocolchicoside, or other NSAIDs. It is contraindicated in patients with active peptic ulcers, severe heart, liver, or kidney disease and in those with a history of cardiovascular disease. Pregnant and breastfeeding women should avoid this medication unless directed by a physician. Caution is advised in patients with seizure disorders, as thiocolchicoside might lower the seizure threshold
Drug Interactions:
Etoricoxib may interact with anticoagulants, antihypertensives, lithium, and other NSAIDs, enhancing adverse effects or reducing efficacy. Thiocolchicoside’s sedative effects can be potentiated by alcohol or other CNS depressants. It is important to inform the doctor of all concurrent medications to avoid harmful interactions
Warnings and Regulatory Status:
Due to the potential cardiovascular risks associated with COX-2 inhibitors, etoricoxib-containing products carry warnings regarding increased risk for heart attack and stroke, especially with long-term use or in high-risk patients. Steriscox MR 4 is approved by regulatory authorities for the indicated uses, and patients should use it under medical supervision
Patient Advice and Tips:
Take the medicine exactly as prescribed.
Avoid alcohol and CNS depressants while on thiocolchicoside.
Report any signs of allergic reaction, severe abdominal pain, or cardiovascular symptoms immediately.
Use the lowest effective dose for the shortest duration to control symptoms.
Inform your healthcare provider of your medical history and medications.
Availability:
Steriscox MR 4 is available in tablet form, branded and marketed by Steris Healthcare Pvt Ltd in various pharmacies and medical stores.
Frequently Asked Questions:
What is Steriscox MR 4 used for?
It is used to relieve pain and muscle spasms due to inflammatory musculoskeletal conditions.Can I take Steriscox MR 4 during pregnancy?
It is generally not recommended; consult your doctor before use.Are there any serious side effects?
Possible risks include cardiovascular events and allergic reactions; seek medical attention if severe symptoms occur.How long does it take to work?
Pain relief and muscle relaxation are typically noticeable within days of starting therapy.Can it be taken with other painkillers?
Avoid taking other NSAIDs or blood thinners simultaneously without consulting your doctor.
Why Choose Steris Healthcare Pvt Ltd?
Steris Healthcare Pvt Ltd is known for delivering high-quality pharmaceutical formulations manufactured following stringent quality standards. Their commitment to effective, safe, and affordable medications makes Steriscox MR 4 a reliable option for managing musculoskeletal pain and spasms.
Conclusion:
Steriscox MR 4, combining etoricoxib 60mg thiocolchicoside 4mg, offers a potent, balanced approach to managing pain and muscle spasms with proven efficacy and a well-characterized safety profile. Patients suffering from inflammatory and muscle spasm-related conditions can benefit significantly from this combination under medical guidance.
