Introduction
Type 2 diabetes mellitus is a chronic metabolic disorder that requires effective and sustained glycemic control to prevent long-term complications. GLICLAGLAZE M 80 is a combination oral antidiabetic medicine containing gliclazide 80 mg and metformin 500 mg, designed to manage blood glucose levels efficiently in patients with type 2 diabetes. This dual-drug formulation works through complementary mechanisms—enhancing insulin secretion while improving insulin sensitivity—making it a trusted option for patients whose blood sugar levels are not adequately controlled with diet, exercise, or monotherapy. GLICLAGLAZE M 80 helps maintain stable glucose levels and supports overall metabolic health when used as prescribed.
Uses
GLICLAGLAZE M 80 is primarily used for:
Management of type 2 diabetes mellitus in adults
Controlling fasting and postprandial blood glucose levels
Patients inadequately controlled on Metformin or sulfonylurea alone
Reducing the risk of diabetes-related complications such as neuropathy, nephropathy, and cardiovascular conditions
This medication is not intended for type 1 diabetes or diabetic ketoacidosis.
Benefits
GLICLAGLAZE M 80 offers multiple benefits through its synergistic formulation:
Dual-action glucose control: Gliclazide stimulates insulin release, while metformin improves insulin sensitivity and reduces glucose production in the liver.
Effective glycemic regulation: Helps maintain stable blood sugar levels throughout the day.
Reduced insulin resistance: Metformin improves the body’s response to insulin.
Lower risk of long-term complications: Consistent glucose control helps protect organs and blood vessels.
Convenient combination therapy: Reduces pill burden and improves treatment adherence.
Weight-neutral effect: Metformin supports weight management in diabetic patients.
Dosage
The dosage of GLICLAGLAZE M 80 should always be determined by a healthcare professional based on individual blood glucose levels and clinical response.
Typically taken once or twice daily, preferably with meals
Tablets should be swallowed whole with water
Do not crush, chew, or break the tablet
Regular blood sugar monitoring is advised during treatment
Dose adjustments may be required in elderly patients or those with kidney impairment
Never change the dosage or discontinue the medicine without consulting your doctor.
Side Effects
GLICLAGLAZE M 80 is generally well tolerated, but some patients may experience mild to moderate side effects, including:
Hypoglycemia (low blood sugar), especially if meals are skipped
Nausea, vomiting, or abdominal discomfort
Diarrhoea or flatulence
Headache or dizziness
Metallic taste in the mouth
Rare but serious side effects such as lactic acidosis may occur with metformin, especially in patients with kidney dysfunction. Seek immediate medical attention if severe symptoms occur.
Precautions and Warnings
Not recommended for patients with severe kidney or liver disease
Use cautiously in elderly patients and those with cardiovascular conditions
Alcohol intake should be avoided, as it increases the risk of hypoglycemia and lactic acidosis
Inform your doctor about all medications you are taking to prevent drug interactions
Regular monitoring of blood glucose, kidney function, and liver function is essential
Not suitable during pregnancy or breastfeeding unless prescribed by a doctor
Keep the medicine out of reach of children and store it in a cool, dry place.
FAQs;
1. What is GLICLAGLAZE M 80 used for?
GLICLAGLAZE M 80 is used to control blood sugar levels in adults with type 2 diabetes mellitus, especially when single-drug therapy is insufficient.
2. How does GLICLAGLAZE M 80 work?
Gliclazide increases insulin secretion from the pancreas, while metformin reduces glucose production in the liver and improves insulin sensitivity.
3. When should I take GLICLAGLAZE M 80?
It is usually taken with meals to reduce the risk of low blood sugar and stomach discomfort, as advised by your doctor.
4. Can GLICLAGLAZE M 80 cause hypoglycemia?
Yes, low blood sugar can occur, especially if meals are skipped or alcohol is consumed. Regular monitoring is important.
5. Is GLICLAGLAZE M 80 safe for long-term use?
Yes, when taken under medical supervision with regular monitoring, it is safe and effective for long-term diabetes management.
6. Can elderly patients take GLICLAGLAZE M 80?
Yes, but dosage adjustments and close monitoring may be required due to kidney function changes with age.
7. Can GLICLAGLAZE M 80 be taken with insulin?
In some cases, doctors may prescribe it along with insulin. Always follow medical advice.
8. What should I do if I miss a dose?
Take the missed dose as soon as you remember unless it is close to the next dose. Do not double the dose.
9. Is GLICLAGLAZE M 80 suitable during pregnancy?
No, it should be used during pregnancy only if clearly advised by a healthcare professional.
10. Where can I buy GLICLAGLAZE M 80 in India?
GLICLAGLAZE M 80 is available at licensed pharmacies and authorized online medical platforms across India.
Conclusion
GLICLAGLAZE M 80 is an effective and reliable combination therapy for the management of type 2 diabetes mellitus. By combining the insulin-stimulating action of gliclazide with the insulin-sensitizing effect of metformin, it provides comprehensive blood sugar control and reduces the risk of long-term diabetic complications. When used alongside a healthy diet, regular exercise, and routine monitoring, GLICLAGLAZE M 80 helps patients achieve better glycemic stability and improved quality of life.
