Introduction
ORAVERSE M is a scientifically formulated combination of myo-inositol and metformin hydrochloride, designed to address metabolic and hormonal imbalances in women, particularly those with polycystic ovary syndrome (PCOS). This unique formulation combines Myo-inositol IP 600 mg and Metformin Hydrochloride 500 mg in sustained-release form to provide optimal therapeutic effects with improved gastrointestinal tolerance. Healthcare professionals widely recommend myo-inositol and metformin hydrochloride tablets for restoring ovulatory function, managing insulin resistance, and supporting overall reproductive health.
Chemical Composition and Formulation
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Active Ingredients:
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Myo-inositol IP – 600 mg
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Metformin Hydrochloride – 500 mg (Sustained Release)
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Dosage Form: Oral tablets
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Brand Name: ORAVERSE M
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Manufacturer: Steris Healthcare
Mechanism of Action
Myo-inositol:
Acts as an insulin sensitizer and plays a vital role in improving ovarian function and reducing hyperandrogenism. It modulates key enzymes involved in glucose metabolism and enhances oocyte quality.
Metformin Hydrochloride:
A biguanide that reduces hepatic glucose production, enhances insulin sensitivity, and decreases intestinal glucose absorption. It also helps regulate menstrual cycles and reduce androgen levels.
Together, myo-inositol and metformin hydrochloride work synergistically to combat insulin resistance, promote hormonal balance, and restore reproductive function in PCOS patients.
Uses and Indications
Myo-inositol and metformin hydrochloride SR tablets uses include:
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Management of Polycystic Ovary Syndrome (PCOS)
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Regulation of menstrual cycles
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Improvement in ovulation and fertility
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Management of insulin resistance and hyperinsulinemia
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Support for weight reduction in metabolic syndrome
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Improvement in lipid profile and reduction of androgen levels
Dosage and Administration
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Recommended Dose: One tablet of ORAVERSE M once or twice daily, or as directed by a healthcare provider.
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Should be taken with meals to minimize gastrointestinal side effects.
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For optimal results, therapy should be continued for at least 3–6 months under medical supervision.
Efficacy and Clinical Evidence
Clinical studies support the combined use of myo-inositol and metformin hydrochloride in improving ovulatory function and reducing insulin resistance in PCOS patients. Trials have demonstrated enhanced fertility outcomes, improved menstrual regularity, and better metabolic control compared to either agent alone.
Side Effects and Safety Profile
Most side effects are mild and transient. They include:
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Nausea
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Abdominal discomfort
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Diarrhea
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Mild gastrointestinal upset (usually transient with SR formulation)
The sustained-release form in ORAVERSE M ensures better tolerance and minimal GI disturbances.
Contraindications and Precautions
Contraindications:
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Renal impairment
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Hepatic dysfunction
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Known hypersensitivity to inositol or metformin
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Acute or chronic metabolic acidosis, including diabetic ketoacidosis
Precautions:
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Monitor renal function before and during treatment
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Avoid alcohol due to risk of lactic acidosis
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Use with caution in elderly patients
Drug Interactions
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Cimetidine and other drugs that affect renal clearance may increase metformin levels.
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Diuretics, NSAIDs, and ACE inhibitors may alter metformin elimination.
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Concomitant use with insulin or sulfonylureas may increase risk of hypoglycemia.
Warnings and Regulatory Status
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Not recommended in pregnancy without medical advice
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Use only under medical supervision in patients with metabolic disorders
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Approved in India and globally for management of insulin resistance and PCOS-related disorders
Patient Advice and Tips
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Take myo-inositol and metformin hydrochloride tablets with food
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Follow a healthy diet and exercise regularly
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Do not skip doses or discontinue without consulting your doctor
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Report any unusual fatigue, muscle pain, or breathing issues (possible signs of lactic acidosis)
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Keep well-hydrated to avoid kidney strain
Availability
ORAVERSE M is available in pharmacy outlets and hospitals across India and select international markets. It is marketed by Steris Healthcare, a trusted name in women's health solutions.
Frequently Asked Questions
1. What are the main benefits of myo-inositol and metformin hydrochloride tablets?
These tablets help regulate menstrual cycles, improve fertility, and manage insulin resistance in PCOS.
2. Can ORAVERSE M help with weight loss in PCOS?
Yes, by improving insulin sensitivity, it may support weight management alongside lifestyle changes.
3. Are there any serious side effects?
Side effects are generally mild, such as nausea or bloating. Rarely, metformin can cause lactic acidosis.
4. How long should I take myo-inositol and metformin hydrochloride?
A typical course lasts 3–6 months or as prescribed by your physician.
5. Can I take ORAVERSE M during pregnancy?
Use during pregnancy should only be under medical supervision, especially in women with insulin resistance.
Why Choose Steris Healthcare?
Steris Healthcare is committed to delivering high-quality, evidence-based formulations that are both effective and affordable. ORAVERSE M reflects Steris's dedication to women's reproductive health and metabolic balance. With state-of-the-art manufacturing and strict quality standards, Steris products are trusted by clinicians and patients alike.
Conclusion
ORAVERSE M, containing myo-inositol and metformin hydrochloride, is a clinically validated, well-tolerated formulation for the effective management of PCOS and insulin resistance. Its dual-action formula not only addresses hormonal imbalance but also supports reproductive and metabolic wellness. Backed by Steris Healthcare’s quality assurance, myo-inositol and metformin hydrochloride tablets offer a reliable choice for women seeking a healthier, balanced life.
