Introduction
PIMASERIN 34 is a cutting-edge neurological product by Steris Healthcare, formulated with pimavanserin 34 mg — a first-in-class atypical antipsychotic used specifically for the treatment of Parkinson’s disease psychosis (PDP). This innovative therapy is available as a pimavanserin 34 mg capsule, designed to reduce hallucinations and delusions without interfering with dopamine signaling, thus preserving motor function.Unlike traditional antipsychotics, pimavanserin targets serotonin 5-HT2A receptors while sparing dopamine pathways, making it exceptionally safe and effective for use in Parkinson’s patients.Mechanism of Action
Pimavanserin acts as a selective inverse agonist and antagonist at the serotonin 5-HT2A receptors, with lesser activity at 5-HT2C receptors in the brain. Unlike typical antipsychotics, it does not block dopamine receptors, which helps reduce psychotic symptoms without causing worsening of motor functions. This selective mechanism makes pimavanserin 34 mg effective in managing psychosis related to Parkinson’s disease with fewer movement-related side effects.
Uses and Indications
Pimavanserin 34 mg is indicated for:
Treatment of hallucinations and delusions associated with Parkinson's disease psychosis (PDP)
Off-label use may include psychosis in other neurodegenerative disorders under medical supervision
Pimavanserin Dose and Administration
The recommended dose is one pimavanserin 34 mg capsule orally once daily, with or without food.
Dose adjustments may be needed in patients with hepatic impairment.
Treatment duration is individualized based on clinical response and tolerability.
Efficacy and Clinical Evidence
Clinical trials have demonstrated that pimavanserin 34 mg significantly reduces psychosis symptoms in Parkinson's disease without worsening motor function. It improves quality of life by controlling hallucinations and delusions. Long-term studies affirm its safety and maintenance of efficacy over extended periods.
Side Effects and Safety Profile
Common side effects include:
Peripheral edema
Nausea
Confusion and hallucinations (paradoxical reactions)
Constipation and dry mouth
Serious side effects are rare but include:
QT interval prolongation (monitoring recommended)
Allergic reactions
Falls and gait disturbances
Contraindications and Precautions
Hypersensitivity to pimavanserin or capsule components
Patients with a known QT prolongation or on QT-prolonging medications need caution
Use in pregnancy and breastfeeding only if benefits outweigh risks
Caution in severe hepatic impairment
Drug Interactions
Metabolized mainly by CYP3A4 and CYP3A5 enzymes; strong inhibitors or inducers of these enzymes may affect drug levels.
Avoid concomitant use with other QT-prolonging drugs.
Careful monitoring when used with other CNS-active agents.
Warnings and Regulatory Status
Approved by FDA in 2016 for Parkinson’s disease psychosis.
Patients should inform physicians about all medications to avoid interactions.
Regular cardiac monitoring recommended due to potential QT prolongation risk.
Adherence to prescribing information is crucial to minimize side effects.
Patient Advice and Tips
Take pimavanserin 34 mg capsule exactly as prescribed, at the same time each day.
Avoid alcohol and other sedatives unless advised by a healthcare provider.
Report any new or worsening symptoms including palpitations or fainting.
Store capsules at room temperature, away from moisture and heat.
Do not stop medication abruptly without consulting your doctor.
Availability
PIMASERIN 34 is available as oral capsules containing pimavanserin 34 mg, distributed by Steris Healthcare. It is accessible in pharmacies and hospitals where prescribed.
Frequently Asked Questions
1. How does pimavanserin work?
Pimavanserin works by selectively blocking serotonin 5-HT2A receptors in the brain, reducing hallucinations and delusions without affecting dopamine receptors, which helps preserve motor function.
2. What is the typical pimavanserin dose?
The standard dose is one pimavanserin 34 mg capsule orally once daily.
3. Why choose Steris Healthcare for pimavanserin?
Steris Healthcare ensures high-quality manufacturing standards, regulatory compliance, and consistent supply for safe and effective pimavanserin 34 mg capsules.
4. Can pimavanserin be taken with other medications?
It is metabolized by liver enzymes CYP3A4/5, so drugs affecting these enzymes can alter pimavanserin levels. Always inform your healthcare provider of all medications.
5. What precautions should patients take while on pimavanserin?
Patients should avoid sudden dose changes, report cardiac symptoms immediately, and undergo regular monitoring as directed by their physician.
Conclusion
PIMASERIN 34, containing pimavanserin 34 mg, stands out as a selective serotonin receptor modulator offering effective treatment of psychosis related to Parkinson's disease with a favorable safety profile. Its unique mechanism avoids common side effects seen with other antipsychotics, making it a valuable option. Proper adherence, monitoring, and choosing a trusted manufacturer like Steris Healthcare support optimal therapeutic outcomes with this medication.
