Introduction
Tab Acetazolamide 250mg, marketed under the brand name Atzolsmile 250, is a pharmaceutical formulation containing 250mg of Acetazolamide as its active ingredient. Acetazolamide 250mg is a potent diuretic and carbonic anhydrase inhibitor widely used in various medical conditions. This article delves into the detailed profile of Atzolsmile 250, covering its mechanism of action, uses and indications, clinical efficacy, safety profile, and essential patient information.
Chemical Composition
Active Ingredient: Acetazolamide 250mg
Mechanism of Action
Acetazolamide is a carbonic anhydrase inhibitor. It works by preventing the enzyme carbonic anhydrase from facilitating the reabsorption of bicarbonate in the kidneys. This leads to increased excretion of bicarbonate, sodium, potassium, and water, resulting in diuresis. Besides its diuretic effect, acetazolamide reduces the formation of aqueous humor in the eye and cerebrospinal fluid, making it useful in treating glaucoma and conditions involving increased intracranial pressure.
Uses and Indications
Acetazolamide 250mg uses include:
Treatment of glaucoma to reduce intraocular pressure.
Management of edema associated with congestive heart failure.
Adjunct therapy for epilepsy, particularly absence seizures.
Prevention and treatment of acute mountain sickness (altitude sickness).
Treatment of metabolic alkalosis.
Use in certain cases of idiopathic intracranial hypertension.
Efficacy and Clinical Evidence
Clinical studies have demonstrated the effectiveness of acetazolamide tablets in lowering intraocular pressure rapidly, reducing edema, and controlling seizures. Its use in preventing altitude sickness is backed by evidence showing symptom reduction when taken prophylactically. Ongoing clinical evaluations affirm its role in managing idiopathic intracranial hypertension and related conditions.
Side Effects and Safety Profile
Common side effects include:
Tingling sensations in fingers and toes.
Frequent urination.
Taste alterations.
Gastrointestinal disturbances like nausea and vomiting.
Drowsiness or fatigue.
More severe but rare adverse effects may involve allergic reactions, electrolyte imbalance, and kidney stones. Regular monitoring is advised during treatment to ensure safety.
Contraindications and Precautions
Known hypersensitivity to acetazolamide or sulfonamides.
Significant kidney or liver disease.
Adrenal gland insufficiency.
Severe electrolyte imbalance.
Precaution in patients with respiratory acidosis or severe chronic obstructive pulmonary disease (COPD).
Drug Interactions
Interactions may occur with:
Other diuretics, increasing the risk of electrolyte imbalance.
Aspirin and salicylates, leading to increased toxicity.
Amphetamines or lithium, altering drug levels.
Phenytoin and other anticonvulsants.
Always consult healthcare providers before combining medications.
Warnings and Regulatory Status
Atzolsmile 250 complies with regulatory standards in its marketed regions and should be used under medical supervision. Warning includes avoiding use during pregnancy unless clearly needed and careful dose adjustment in renal impairment.
Patient Advice and Tips
Take tab acetazolamide 250mg with food to minimize stomach upset.
Maintain adequate hydration to prevent kidney stones.
Regularly monitor electrolyte levels as advised by your physician.
Report adverse symptoms immediately.
Avoid prolonged exposure to sunlight due to photosensitivity risk.
Availability
Atzolsmile 250 is readily available in pharmacies and through authorized medical suppliers affiliated with Steris Healthcare Pvt Ltd.
Why Choose Steris Healthcare Pvt Ltd?
Steris Healthcare Pvt Ltd is a trusted name in pharmaceutical manufacturing, known for:
Stringent quality control.
Compliance with global regulatory standards.
Innovation in drug formulation.
Extensive distribution networks ensuring medicine availability.
Commitment to patient safety and efficacy.
Choosing Atzolsmile 250 from Steris Healthcare ensures you receive a product backed by quality and reliability.
Frequently Asked Questions
What is acetazolamide 250 mg used for?
It is used for glaucoma, edema, epilepsy, altitude sickness prevention, and intracranial hypertension management.Can acetazolamide be used during pregnancy?
It is generally avoided unless necessary and prescribed by a physician.How quickly does Atzolsmile 250 act?
Effects on intraocular pressure and diuresis can be seen within a few hours.Are there dietary restrictions while on acetazolamide?
Maintaining hydration is essential; discuss any special diet with the doctor.What should I do if I miss a dose?
Take it as soon as remembered unless close to the next dose; avoid doubling doses.
Tab Acetazolamide 250mg as available in Atzolsmile 250 offers an effective and reliable solution for several medical conditions involving fluid balance, pressure regulation, and seizures. With proven clinical efficacy, a well-understood safety profile, and support from a reputable manufacturer like Steris Healthcare Pvt Ltd, it stands as a preferred choice for healthcare providers and patients alike. Proper usage, adherence to safety guidelines, and consultation with healthcare professionals will maximize benefits and minimize risks during treatment.
