Introduction
Voriconazole 200 mg is a broad-spectrum triazole antifungal medication widely used to combat serious fungal infections. Available in tablet form (including the voriconazole 200 mg tablet), voriconazole works by inhibiting fungal growth, thereby helping the immune system clear infections. The drug is particularly indispensable for infections caused by Aspergillus species and Candida species, among others. The brand Vinocanazol 200 specifically contains 200 mg of this active compound.
Mechanism of Action
Voriconazole targets fungal cell membranes by inhibiting the enzyme lanosterol 14-alpha-demethylase (also known as CYP51), which is essential in the biosynthesis of ergosterol, a critical component of fungal cell membranes. This inhibition disrupts ergosterol synthesis, impairing fungal cell membrane integrity and function, leading to halted fungal growth. It acts fungicidally against Aspergillus species and fungistatically against Candida species.
Uses and Indications
Voriconazole tablet (including the 200 mg strength) is primarily indicated for:
Treatment of invasive aspergillosis
Systemic candidiasis (candidemia), especially fluconazole-resistant strains
Esophageal candidiasis (infection of the esophagus)
Other severe fungal infections, especially in immunocompromised patients
It is ideal for patients who have failed other antifungal treatments or who have resistant infections.
Efficacy and Clinical Evidence
Clinical studies demonstrate voriconazole's high bioavailability (approximately 96% in adults) and significant efficacy in reducing fungal burden. It shows superior outcomes in invasive aspergillosis compared with older antifungals. It has demonstrated improvement in survival rates and treatment responses in systemic fungal infections, making the voriconazole 200 mg tablet a preferred option among antifungal therapies.
Side Effects and Safety Profile
Common side effects include visual disturbances (such as blurred vision and light sensitivity), nausea, rash, headache, and liver enzyme elevations. Serious but less frequent adverse effects include hepatotoxicity, photosensitivity reactions that may precede skin malignancies, and potential cardiac rhythm abnormalities. Monitoring is recommended during therapy to detect and manage adverse reactions promptly.
Contraindications and Precautions
Voriconazole is contraindicated in patients with known hypersensitivity to voriconazole or its excipients. It should not be used during pregnancy due to potential fetal toxicity. Caution is advised in patients with pre-existing liver disease, cardiac arrhythmias, and in those taking medications that prolong the QT interval.
Drug Interactions
Voriconazole strongly inhibits CYP3A4, CYP2C19, and CYP2C9 enzymes, leading to significant interactions with numerous drugs, including:
Corticosteroids (e.g., dexamethasone)
Immunosuppressants (e.g., sirolimus)
Antiepileptics (e.g., phenytoin, carbamazepine)
HIV medications (e.g., ritonavir)
Others such as rifampin and St. John’s wort
Patients must inform their healthcare providers of all medications they are using to avoid harmful interactions.
Warnings and Regulatory Status
Voriconazole carries warnings for potential phototoxicity and risk of skin cancers with prolonged use. It is approved and regulated globally for use in adults and pediatric patients aged 2 years and above for serious fungal infections.
Patient Advice and Tips
Take voriconazole 200 mg tablet on an empty stomach, 1 hour before or after meals.
Follow dosing schedules precisely, usually twice daily.
Avoid direct sunlight or use sun protection due to photosensitivity risk.
Report any side effects, especially visual changes or symptoms of liver issues, to your doctor immediately.
Inform the healthcare provider about all current medications to prevent interactions.
Availability
Vinocanazol 200 (voriconazole 200 mg) tablets are widely available in India and other countries through pharmacies and healthcare providers.
Frequently Asked Questions
What is voriconazole 200 mg used for?
Voriconazole 200 mg is used to treat serious fungal infections such as invasive aspergillosis, candidemia, and esophageal candidiasis, especially when other treatments fail or are not suitable.How does voriconazole work?
It inhibits ergosterol synthesis in fungal cell membranes, disrupting fungal growth.What should I do if I miss a dose?
Take the missed dose as soon as remembered unless it is almost time for the next dose. Do not double dose.Are there any serious side effects?
Yes, including liver toxicity, vision changes, and skin reactions. Regular monitoring by your healthcare provider is essential.Why choose Steris Healthcare Pvt Ltd?
Steris Healthcare Pvt Ltd is known for manufacturing high-quality pharmaceuticals with stringent quality controls, ensuring the efficacy and safety of Vinocanazol 200.
