DIOWELPREX ER 250

Description

DIOWELPREX ER 250 is a clinically approved extended-release antiepileptic and mood-stabilizing medication containing Divalproex Sodium 250 mg. This formulation is widely used to treat epilepsy, bipolar disorder, and migraine prophylaxis. As a divalproex extended release tablet, it provides steady drug levels over 24 hours, ensuring consistent symptom control with improved patient compliance. Designed to be taken once daily, DIOWELPREX ER 250 helps maintain stable blood concentrations of valproate, minimizing side effects and seizure recurrence. What is DIOWELPREX ER 250 (Tab Divalproex 250 mg)? DIOWELPREX ER 250 is an extended-release tablet containing Divalproex Sodium 250 mg, which delivers Valproic Acid, a well-known broad-spectrum anticonvulsant. It is available as tab divalproex 250 mg and is often preferred for its stable and sustained release, especially in long-term neurological or psychiatric conditions. Divalproex 250 mg Uses DIOWELPREX ER 250 is prescribed for: 1. Epilepsy / Seizure Disorders Focal seizures Generalized tonic-clonic seizures Complex partial seizures Absence seizures 2. Bipolar Disorder Acute mania Maintenance therapy for mood stabilization 3. Migraine Prevention Helps reduce the frequency and severity of migraine attacks 4. Off-Label Uses (under medical supervision) Schizoaffective disorder Impulsive aggression Neuropathic pain Alcohol withdrawal (in select cases) Mechanism of Action of Divalproex Divalproex Sodium dissociates into valproate ions, which: Enhance GABA (gamma-aminobutyric acid) levels in the brain, an inhibitory neurotransmitter Inhibit voltage-gated sodium and calcium channels Reduce neuronal hyperexcitability, preventing seizures and mood fluctuations This multi-targeted mechanism makes DIOWELPREX ER 250 effective across various neurological and psychiatric conditions. Dosage and Administration of Divalproex 250 ER Usually taken once daily due to the extended-release property Can be taken with or without food Swallow whole; do not crush or chew the tablet Dosage is adjusted based on: Body weight Severity of condition Serum valproate levels Clinical response Note: Regular blood tests may be needed to monitor liver function, platelet count, and valproate levels. Divalproex 250 mg Side Effects Common Side Effects: Nausea, vomiting Drowsiness Dizziness Weight gain Hair thinning Tremor Increased appetite Serious Side Effects: Liver toxicity (especially in young children) Pancreatitis Low platelet count (thrombocytopenia) Severe allergic reactions (DRESS syndrome, rash) Mood changes or suicidal thoughts Seek medical attention immediately if symptoms like abdominal pain, jaundice, unusual bruising, or confusion occur. Precautions Before Using DIOWELPREX ER 250 Not recommended during pregnancy unless absolutely necessary — may cause birth defects Use with caution in elderly patients and those with liver disease Avoid alcohol as it may increase sedation and liver stress Inform your doctor if you have: Family history of liver disease Bleeding disorders Pancreatitis Metabolic disorders (like urea cycle disorder) Monitoring: Liver function tests CBC (Complete Blood Count) Serum ammonia levels (if encephalopathy is suspected) Drug Interactions What Drugs Interact with Divalproex 250 mg? Divalproex can interact with: Anticonvulsants: Phenytoin, Carbamazepine, Lamotrigine – May alter drug levels or increase toxicity Antipsychotics and Antidepressants: Olanzapine, Quetiapine, SSRIs – Risk of increased sedation or mood instability Blood Thinners: Aspirin, Warfarin – May increase bleeding risk CNS Depressants: Alcohol, benzodiazepines – Additive sedative effects Hormonal Contraceptives: May lower valproate levels and effectiveness Always inform your healthcare provider of all medications and supplements being taken. Conclusion DIOWELPREX ER 250 is a reliable and effective treatment option for epilepsy, bipolar disorder, and migraine prevention. Its extended-release formulation provides consistent drug levels, better tolerability, and once-daily convenience, making it an ideal choice for long-term therapy.