Diltiazem Hydrochloride 120 mg: Mechanism, Uses, and Safety

Introduction

DILTIAZONE SR 120 contains Diltiazem Hydrochloride 120mg, formulated as diltiazem hydrochloride sustained release tablets. It belongs to the calcium channel blocker class of medicines, primarily used to manage cardiovascular conditions such as high blood pressure, chronic stable angina, and certain types of arrhythmias. With its sustained release formulation, it ensures a gradual release of medicine in the bloodstream, offering long-lasting therapeutic effects. This makes DILTIAZONE SR 120 a reliable choice for patients requiring stable heart rate control and blood pressure regulation.

Mechanism of Action

Diltiazem Hydrochloride works by inhibiting the influx of calcium ions into cardiac and smooth muscle cells. This action relaxes blood vessels, reduces myocardial oxygen demand, and improves blood flow to the heart muscle. In sustained release form, the drug maintains steady therapeutic levels for extended durations, enhancing patient compliance.

Uses and Indications

DILTIAZONE SR 120mg is prescribed for:

• Hypertension (High Blood Pressure) – Helps lower blood pressure and reduce the risk of stroke and heart attack.

• Chronic Stable Angina – Relieves chest pain by improving blood and oxygen supply to the heart.

• Arrhythmias – Manages certain abnormal heart rhythms, especially atrial fibrillation and supraventricular tachycardia.

Efficacy and Clinical Evidence

Clinical trials have shown that diltiazem hydrochloride tablets in sustained release form effectively reduce blood pressure and angina episodes. Studies also indicate a positive effect on exercise tolerance in patients with coronary artery disease, with minimal impact on heart rate at rest.

Side Effects and Safety Profile

Common side effects may include:

• Headache

• Dizziness

• Flushing

• Swelling of ankles or feet

• Fatigue

Serious side effects are rare but may include slow heart rate, difficulty breathing, or severe hypotension. Patients should immediately report any unusual symptoms to their doctor.

Contraindications and Precautions

Avoid DILTIAZONE SR 120 if you have:

• Severe hypotension

• Advanced heart block

• Sick sinus syndrome (without a pacemaker)

• Recent heart attack with pulmonary congestion

Precautions: Use with caution in patients with liver or kidney impairment and elderly patients.

Drug Interactions

Diltiazem hydrochloride 120 mg may interact with:

• Beta-blockers (risk of excessive heart rate reduction)

• Digoxin (may increase digoxin levels)

• Statins like simvastatin (increased risk of muscle toxicity)

• Antiarrhythmic drugs (possible enhanced cardiac effects)

Warnings and Regulatory Status

• Use only under medical supervision.

• Approved by regulatory authorities for cardiovascular indications.

• Not recommended for use during pregnancy unless absolutely necessary.

Patient Advice and Tips

• Take the medicine at the same time each day.

• Do not crush or chew sustained release tablets.

• Maintain a healthy diet and limit salt intake.

• Avoid sudden discontinuation; taper under doctor’s advice.

Availability

DILTIAZONE SR 120 is available in the Indian pharmaceutical market from Steris Healthcare Pvt. Ltd., ensuring high quality, efficacy, and affordability.

Why Choose Steris Healthcare Pvt. Ltd.?

Steris Healthcare is a trusted pharmaceutical company committed to delivering high-quality, affordable medicines that meet stringent regulatory standards. With a focus on patient safety, innovation, and therapeutic effectiveness, Steris Healthcare ensures that DILTIAZONE SR 120 meets the highest benchmarks for quality, purity, and clinical performance.

Frequently Asked Questions

1. What is Diltiazem Hydrochloride?
It is a calcium channel blocker used to treat high blood pressure, angina, and certain arrhythmias.

2. How does DILTIAZONE SR 120 work?
It relaxes blood vessels and improves heart oxygen supply by blocking calcium entry into muscle cells.

3. Can I take this medicine with food?
Yes, it can be taken with or without food, but preferably at the same time daily.

4. Is it safe for elderly patients?
Yes, but dosage adjustments may be necessary under medical supervision.

5. Can I stop taking it once I feel better?
No, always consult your doctor before discontinuation to prevent rebound hypertension or angina.

Conclusion